Biochem/physiol Actions

Reversible: no

Product does not compete with ATP.

Primary TargetInhibitor of microfilament-mediated processes in sperm, eggs, and embryos

Cell permeable: yes

General description

A cell-permeable marine toxin from the Red Sea sponge Latrunculia magnifica that disrupts microfilament organization in cultured cells by the formation of a 1:1 complex with monomeric G-actin (K_d = 200 nM). Also a potent inhibitor of microfilament-mediated processes in sperm, eggs, and embryos.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Ayscough, K.R., et al. 1997. J. Cell Biol.137, 399.Spector, I., et al. 1989. Cell Motil. Cytoskeleton13, 127.Coue, M., et al. 1987. FEBS Lett.213, 316.Schatten, G., et al. 1986. Exp. Cell Res.166, 191.Spector, I., et al. 1983. Science219, 493.

Packaging

Packaged under inert gas

50 µg in Plastic ampoule

Physical form

A 1 mM (50 µg/119 µl) solution of Latrunculin A, Latrunculia magnifica Cat. No. 428021 in DMSO.

Reconstitution

Following initial use, aliquot and freeze (-20°C).

Warning

Toxicity: Harmful (C)